Define the active and the comparison
Identify the ingredient, intended use and reference formulation before selecting a delivery approach. Write down what a successful comparison would show and how it would influence the business decision. An ingredient supplier's platform data may help frame the question but does not replace evaluation of the proposed finished product.
Characterize the system you intend to sell
Build a technical brief that identifies the appropriate characterization work, potentially including particle-size distribution, encapsulation assessment and stability measures. Methods should fit the formulation. Agree what will be measured, by whom and at which development stage before positioning the concept around those measurements.
Connect shelf life to the finished format
Liquid, sachet and dry-format concepts create different processing and packaging questions. Assess the delivery system after processing and in its intended pack, not only in an early bench sample. Establish the storage assumptions and changes that would trigger a reformulation or further study.
A USEFUL STARTING POINT
Bring these three decisions.
- Active ingredient and target format
- Reference formulation or comparator
- Desired evidence and storage conditions
PCG can scope concept definition, formulation and prototype work, sourcing, and the manufacturing handoff around your priorities. Deliverables, timing, testing and ownership terms are agreed for the project. Manufacturing is performed by the selected CDMO.
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BEFORE WE BEGIN
Liposomal formulation: your questions.
Does liposomal automatically mean better absorption?
No. The claim needs evidence appropriate to the actual formulation and comparison. PCG can help define a research brief; the delivery-system name alone is not a performance result.
Can a liposomal concept be evaluated as a powder?
Yes, as a development question. The brief should identify how processing and reconstitution will be evaluated and what evidence supports describing the finished format as liposomal.
Is a bioavailability study included?
Research is separately scoped and quoted. First define the formulation, comparator and endpoint so study costs answer a meaningful product question.